Sodium cyanoborohydride → HCID 56967032, compound

Participants

Reaction Steps

Add to a solution of 3-[4-(4-cyano-phenyl)-[1,2,3]triazol-1-ylmethyl]-N—[(R)-6-(2-methoxy-ethylamino)-4,5,6,7-tetrahydro-benzothiazol-2-yl]-benzamide (0.13 g, 0.20 mmol) in 5 mL MeOH formalin (0.3 mL) and sodium cyanoborohydride (51 mg, 0.82 mmol). Stir the mixture at room temperature for 2 h. Add sat. NH4Cl to the mixture to quench any unreacted sodium cyanoborohydride. Concentrate the mixture, concentrate and purify via preparative HPLC to afford 0.06 g, 58% yield of 3-[4-(4-cyano-phenyl)-[1,2,3]triazol-1-ylmethyl]-N-{(R)-6-[(2-methoxy-ethyl)-methyl-amino]-4,5,6,7-tetrahydro-benzothiazol-2-yl}-benzamide. MS, ES+ 528.44 (M+H), rt 5.33 min

Provenance & Evidence