p-Toluenesulfonic acid → HCID 67507811, compound

Participants

Reaction Steps

Heat a solution of 4-(4,4-difluoro-piperidin-1-yl)-cyclohexanone (1.93 g 8.88 mmol), pyrrolidine (0.89 mL, 10.7 mmol) and p-toluenesulfonic acid (1 crystal) in cyclohexane (50 mL) to reflux with a Dean-Stark trap for 7 h. Cool the solution and filter through a plug of cotton wool. Evaporate to give 2.31 g, 96% yield of 4,4-difluoro-1-(4-pyrrolidin-1-yl-cyclohex-3-enyl)-piperidine as an oil.

Provenance & Evidence