Potassium Carbonate → HCID 178497711, compound

Participants

Reaction Steps

Suspend 4-(2-bromo-acetyl)-benzonitrile (0.11 g, 0.48 mmol), K2CO3 (0.28 g, 2.00 mmol) and a 2:1 mixture of 3-carbamimidoylmethyl-benzoic acid methyl ester hydrochloride/3-carbamimidoylmethyl-benzamide hydrochloride (0.14 g) into 5 mL of 4:1 THF/H2O. Heat the mixture to reflux for 2 h. Concentrate the mixture to dryness and dissolve into 20 mL of H2O. Add 5% aq HCl until pH is acidic. Extract with 2×20 mL of CH2Cl2. Dry organic phase with MgSO4, filter and concentrate to give 0.13 g of crude 3-[4-(4-cyano-phenyl)-1H-imidazol-2-ylmethyl]-benzoic acid methyl ester and 3-[4-(4-cyano-phenyl)-1H-imidazol-2-ylmethyl]-benzamide as a purple residue.

Provenance & Evidence