Sodium Hydroxide → HCID 178509595, compound

Participants

Reaction Steps

Dissolve the mixture of crude 3-[4-(4-cyano-phenyl)-1H-imidazol-2-ylmethyl]-benzoic acid methyl ester and 3-[4-(4-cyano-phenyl)-1H-imidazol-2-ylmethyl]-benzamide (0.13 g) into 5 mL of 1:1 THF/MeOH. To this add 0.5 mL of 15% NaOH. Stir the mixture at room temperature for 2 h. Add 1 mL of 15% NaOH and stir an additional 2 h. Concentrate to dryness. Dissolve the residue into 5 mL of H2O and make acidic by the addition of 5% HCl. Extract with 3×10 mL of CH2Cl2 and dry with MgSO4. Concentrate to give 0.13 g of crude 3-[4-(4-cyano-phenyl)-1H-imidazol-2-ylmethyl]-benzoic acid and 3-[4-(4-cyano-phenyl)-1H-imidazol-2-ylmethyl]-benzamide as a purple residue.

Provenance & Evidence