4-Toluenesulfonyl chloride → HCID 87111133, compound

Participants

Reaction Conditions

Reaction Steps

To 50 gms (0.24 mole) of 4-(3′-Hydroxypropoxy)-3-methoxy benzonitrile in 200 ml. of cyclohexane was added 26 gms (0.24 mole) of sodium carbonate and 46 gms (0.24 mole) of p-toluene sulfonyl chloride at once. The resultant reaction mixture was refluxed for about 4-6 hrs. After completion of the reaction, the reaction mass was cooled to about 25-30° C. and the inorganic salts were filtered off. and washed with cyclohexane. The solvents were distilled completely and solid obtained was recrystallized from 150 ml of ethyl acetate to afford the title compound as white crystalline powder.

Provenance & Evidence