HCID 123543803, compound → HCID 89750507, compound

Participants

Reaction Steps

5-(Bicyclo[2.2.1]heptan-2-yl)-4-methylpent-4-enal (20.6 g; 107 mmol) was hydrogenated in ethyl acetate (70 ml) in the presence of 5% palladium on charcoal (1.4 g) at room temperature and 30 bars. The product was purified by column chromatography on silica gel (eluent: heptanes/ethyl acetate 9:1) followed by bulb-t-bulb distillation (100° C./0.25 mbar). The product was obtained as a 1:1 mixture of diastereoisomers in 65% yield.

Provenance & Evidence