HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Magnolol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 2,2'-Dimethoxy-5,5'-di(prop-2-en-1-yl)-1,1'-biphenyl | HCID 14864218 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | Magnolol | HCID 72300 | — |
Reaction Steps
The 4,4′-diallyl-2,2′-bianisole is added to a mixture of aluminum chloride, thiourea and 1,2-dichloroethane slowly over 3 hours at 50° C. Temperature and stirring is maintained for an additional 3-4 hours. Reaction mix is cooled and added to HCl and phases are separated. The organic layer is added to charcoal, filtered and the solvent distilled, to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09000231B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-f2509bedd2584364805c2990c05f6bf6 |
| Source note | uspto-grants-2015_04 |