4,5-Dihydro-2-thiazolamine → HCID 89953865, compound

HRID 1468264Notes

Reaction equation

HRID 1468264 reaction equation
[CH:1]1([O:7][CH2:8][C:9]2[N:13]3[CH:14]=[CH:15][C:16]([C:18]([NH:20][C:21]4[S:22][CH:23]=[CH:24][N:25]=4)=[O:19])=[CH:17][C:12]3=[N:11][C:10]=2[CH:26]([CH3:28])[CH3:27])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.NC1SCCN=1>>[CH:1]1([O:7][CH2:8][C:9]2[N:13]3[CH:14]=[CH:15][C:16]([C:18]([NH:20][C:21]4[S:22][CH2:23][CH2:24][N:25]=4)=[O:19])=[CH:17][C:12]3=[N:11][C:10]=2[CH:26]([CH3:28])[CH3:27])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 156894,5-Dihydro-2-thiazolamineHCID 131732702HCID 131732702, compound

Product 1

HCID 89953865HCID 89953865, compound

Procedure

Compound 25 (8.9 mg, yield 14%) was obtained in the same manner as in step 4 of Example 21, using 3-cyclohexyloxymethyl-2-isopropyl[1,2-a]pyridine-7-carboxylic acid obtained in step 3 of Example 21, and 2-amino-4,5-dihydrothiazole.

Sources & evidence

ORD record
ord-318e3778392549bb8a8f4f4cd2d91d2b
Source dataset
uspto-grants-2015_04
Patent number
US09000186B2

Reaction notes

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