Diethyl Ether → HCID 86710048, compound

Participants

Reaction Steps

Compound 13 (237 mg, 0.584 mmol) was dissolved in isobutyl alcohol (1.2 mL), and the solution was stirred overnight under heat and reflux after adding a 5 mol/L sodium hydroxide aqueous solution (1.2 mL). The reaction mixture was stirred after adding diethyl ether, and the aqueous layer was removed. Then, 3 mol/L hydrochloric acid (2.0 mL) was added to the aqueous layer, and the mixture was stirred. The precipitated crystals were collected by filteration to give 3-cyclohexylsulfonyl-2-isopropylimidazo[1,2-a]pyridine-7-carboxylic acid (86.2 mg, yield 42%).

Provenance & Evidence