Chlorotriethylsilane → HCID 86710069, compound

Participants

Reaction Steps

3-(4,4-Difluorocyclohexyl)-1-(1-trifluoromethylcyclopropyl)propan-1-one (0.200 g, 0.704 mmol) obtained in step 3 was dissolved in THF (2.0 mL). Under ice-cooled condition, DBU (0.117 mL, 0.774 mmol) and chlorotriethylsilane (0.130 mL, 0.774 mmol) were added, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was extracted with heptane after adding a saturated sodium hydrogen carbonate aqueous solution. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was then evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=95/5→90/10) to give {3-(4,4-difluorocyclohexyl)-1-(1-trifluoromethylcyclopropyl)prop-1-enyloxy}triethylsilane (0.253 g, yield 90%).

Provenance & Evidence