4-Aminotetrahydropyran hydrochloride → HCID 86710091, compound

HRID 1468283Notes

Reaction equation

HRID 1468283 reaction equation
[F:1][C:2]1([F:32])[CH2:7][CH2:6][CH:5]([CH2:8][C:9]2[N:13]3[C:14]([CH3:27])=[CH:15][C:16]([C:18]([NH:20][CH:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[O:19])=[CH:17][C:12]3=[N:11][C:10]=2[C:28]2(C)[CH2:30][CH2:29]2)[CH2:4][CH2:3]1.FC1(F)CCC(CC2N3C(C)=CC(C(O)=O)=CC3=NC=2C(C)C)CC1.Cl.NC1CCOCC1>>[F:32][C:2]1([F:1])[CH2:7][CH2:6][CH:5]([CH2:8][C:9]2[N:13]3[C:14]([CH3:27])=[CH:15][C:16]([C:18]([NH:20][CH:21]4[CH2:26][CH2:25][O:24][CH2:23][CH2:22]4)=[O:19])=[CH:17][C:12]3=[N:11][C:10]=2[CH:28]([CH3:29])[CH3:30])[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 441186934-Aminotetrahydropyran hydrochlorideHCID 60152106HCID 60152106, compoundHCID 86710092HCID 86710092, compound

Product 1

HCID 86710091HCID 86710091, compound

Procedure

Compound 100 (62.0 mg, yield 72%) was obtained in the same manner as in step 4 of Example 49, using 3-(4,4-difluorocyclohexylmethyl)-2-isopropyl-5-methylimidazo[1,2-a]pyridine-7-carboxylic acid obtained in step 5, and 4-aminotetrahydropyran hydrochloride.

Sources & evidence

ORD record
ord-355ea606834b4d94b592cb8b049d1f1f
Source dataset
uspto-grants-2015_04
Patent number
US09000186B2

Reaction notes

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