反应详情

2-Amino-6-chloroisonicotinic acid (500 mg, 2.90 mmol) was dissolved in ethanol (29.0 mL), and the solution was stirred under heat and reflux for 3 hours after adding thionyl chloride (1.06 mL, 14.5 mmol). The solvent was then evaporated under reduced pressure. The residue was extracted with chloroform after adding a sodium hydrogen carbonate aqueous solution. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give ethyl 2-amino-6-chloroisonicotinate (510 mg, yield 88%).

1. temperatureunder heat
2. temperaturereflux for 3 hours
3. customThe solvent was then evaporated under reduced pressure
4. extractionThe residue was extracted with chloroform
5. additionafter adding a sodium hydrogen carbonate aqueous solution
6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
7. customthe solvent was evaporated under reduced pressure