Chlorosuccinimide → HCID 86710116, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 6-amino-2-methylisonicotinate (2.00 g, 11.1 mmol) was dissolved in DMF (20 mL), and the solution was stirred at 50° C. for 1 hour after adding N-chlorosuccinimide (1.48 g, 11.1 mmol). The reaction mixture was allowed to cool to room temperature, and a sodium hydrogen carbonate aqueous solution was added. The precipitated solid was collected by filteration to give ethyl 6-amino-3-chloro-2-methylisonicotinate (1.36 g, yield 57%).

Provenance & Evidence