4-Amino-6-chloropyrimidine → HCID 86710137, compound

Participants

Reaction Conditions

Reaction Steps

4-Amino-6-chloropyrimidine (100 mg, 0.772 mmol) was suspended in DMF (0.5 mL), and the suspension was stirred overnight at 50° C. after adding 1-bromo-3-methylbutan-2-one (153 mg, 0.920 mmol) and molecular sieve 4A (200 mg). The reaction mixture was allowed to cool to room temperature. After adding a sodium hydrogen carbonate aqueous solution, the mixture was filtered through Celite (registered trademark), and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was then evaporated under reduced pressure. The residue was purified by preparative thin-layer chromatography (chloroform/methanol=98/2) to give 7-chloro-2-isopropylimidazo[1,2-c]pyrimidine (64.7 mg, yield 43%).

Provenance & Evidence