HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-chloro-3-(L-gamma-glutamylamino)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | Methyl 3-amino-5-chlorobenzoate | HCID 52987785 | — |
| Reactant | Boc-Glu-OtBu hydrochloride | HCID 131731743 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-chloro-3-(L-gamma-glutamylamino)benzoic acid | HCID 66614843 | — |
Reaction Steps
HATU, 38 mg (0.1 mmol), 14 mg (0.1 mmol) of HOAt, 30 mg (0.1 mmol) of Boc-Glu-OtBu hydrochloride, 0.014 ml (0.1 mmol) of triethylamine and 1 ml of dichloromethane were added to 30 mg (0.1 mmol) of methyl 5-chloro-3-aminobenzoate. The mixture was stirred at room temperature overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09000208B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-42efbbbcd62340c7b3bf4d578221b63d |
| Source note | uspto-grants-2015_04 |