Ethyl Acetate → [6-Chloro-3-methyl-4-(4-nitro-phenyl)-naphthalen-2-yl]-acetic acid methyl ester

Participants

Reaction Steps

To a mixture of (6-chloro-3-methyl-4-trifluoromethanesulfonyloxy-naphthalen-2-yl)-acetic acid methyl ester (200 mg, 0.5 mmol), 4-nitrophenylboronic acid (170 mg, 1.1 mmol) and cesium carbonate (331 mg, 1 mmol) in dimethoxyethane (3 mL) was added [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (55.3 mg, 0.07 mmol) at room temperature under nitrogen. The resulting mixture was reacted using a microwave reactor (Personal Chemistry) at 120° C. for 30 minutes. Ethyl acetate (10 mL) was added and the organic layer was washed with water (20 mL) and brine solution (20 mL). The organic layers were dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to give the crude product which was purified by using an ISCO (40 g) column chromatography eluting with 5-15% ethyl acetate in hexanes to give [6-chloro-3-methyl-4-(4-nitro-phenyl)-naphthalen-2-yl]-acetic acid methyl ester (138 mg, 74%) as a light yellow solid. 1H NMR (300 MHz, CDCl3), δ ppm 8.40 (d, J=8.6 Hz, 2 H), 7.82 (dd, J=8.9, 5.7 Hz, 1 H), 7.77 (s, 1 H), 7.46 (d, J=8.6 Hz, 2 H), 7.21 (td, J=8.9, 2.4 Hz, 1 H), 6.76 (dd, J=11.2, 2.4 Hz, 1 H), 3.87 (s, 2 H), 3.74 (s, 3 H), 2.14 (s, 3 H). HRMS calcd. for C20H15ClNO4 [(M−H)−] 368.0695, obsd. 368.0695.

Provenance & Evidence