4-Cbz-aminopiperidine → Benzyl 1-(2-(4-(4-acetylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-yl)piperidin-4-ylcarbamate

HRID 146844Notes

Reaction equation

HRID 146844 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:4][CH2:5][N:6]([c:9]2[n:10][c:11]([NH:16][c:17]3[cH:18][cH:19][c:20]([N:23]4[CH2:24][CH2:25][N:26]([C:29]([CH3:30])=[O:31])[CH2:27][CH2:28]4)[cH:21][cH:22]3)[n:12][cH:13][c:14]2[F:15])[CH2:7][CH2:8]1.[NH:32]1[CH2:33][CH2:34][CH:35]([NH:38][C:39]([O:40][CH2:41][c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)=[O:48])[CH2:36][CH2:37]1>>[CH:3]1([NH:38][C:39]([O:40][CH2:41][c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)=[O:48])[CH2:4][CH2:5][N:6]([c:9]2[n:10][c:11]([NH:16][c:17]3[cH:18][cH:19][c:20]([N:23]4[CH2:24][CH2:25][N:26]([C:29]([CH3:30])=[O:31])[CH2:27][CH2:28]4)[cH:21][cH:22]3)[n:12][cH:13][c:14]2[F:15])[CH2:7][CH2:8]1

Participants

3

Reactant 2

HCID 15143044-Cbz-aminopiperidineHCID 444673191-(4-(4-(4-(4-(Aminomethyl)piperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone

Product 1

HCID 44467167Benzyl 1-(2-(4-(4-acetylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-yl)piperidin-4-ylcarbamate

Sources & evidence

ORD record
ord-61649fd84c024c6abe32d28ed245d3b4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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