Maleic Anhydride → HCID 22222645, compound

Participants

Reaction Steps

To a mixture of maleic anhydride (5.0 g. 50.9 mmol) in chloroform (100 ml) was added p-aminophenyl maleamic acid (6.99 g, 50.9 mmol). The resulting mixture was heated to reflux for 3 h. The solution was then cooled and a precipitate formed. The precipitate was filtered, washed with ethyl acetate and dried, to give 2N-(4-carboxyphenyl)maleamic acid (99%) as a solid.14 mp: 218-220° C. 1H NMR (DMSO-d6): δ 6.30 (d, J=12.0 Hz, 1H), 6.47 (d, J=1.20 Hz, 1H), 7.71 (d, J=8.4 Hz, 2H), 7.88 (d, J=8.8 Hz, 2H), 10.59 (s, 1H), 12.83 (brs, 1H); HRMS (m/z): [M−H]− calcd for C11H8NO5, 234.0408; found, 234.0406.

Provenance & Evidence