Acetic Anhydride → 1H-Pyrrole-2,5-dione, 1,1'-(1,8-octanediyl)bis-

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Reaction Steps

The general procedure was carried out using maleic anhydride (14.27 g, 146 mmol), 1,8-octanediamine (10.0 g, 69.3 mmol), sodium acetate (1.14 g, 13.9 mmol) and acetic anhydride (15.57 g, 153 mmol). The resulting compound was purified by column chromatography (98:2 DCM:EtOAc), and the product obtained as a white solid (5.2 g/25%).

Provenance & Evidence