HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromobenzene → HCID 86669532, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromobenzene | HCID 7961 | — |
| Reactant | 2-Amino-3-methoxypyridine | HCID 9920384 | — |
| Reactant | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl | HCID 11269872 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 86669532 | HCID 86669532 | — |
Reaction Steps
A 1 L 3-neck flask is charged with 3-methoxypyridine-2-amine (17.65 g, 143 mmol), bromobenzene (15 g, 96 mmol), Pd2DBA3 (1.75 g, 1.91 mmol), Sodium tert-butoxide (18.36 g, 101 mmol), S-Phos (1.56 g, 3.82 mmole) and 400 mL of xylene. The reaction mixture is refluxed for 4 h. The product is isolated by column chromatography (5% EtoAc in Hexs) to yield the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09005772B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-6cc89e890f624605a0f3539a143943e8 |
| Source note | uspto-grants-2015_04 |