Pyridinium chloride → HCID 178515295, compound

HRID 1468597Notes

Reaction equation

HRID 1468597 reaction equation
C[O:2][C:3]1[N:4]=[CH:5][C:6]2[C:11]([CH:12]=1)=[C:10]1[CH:13]=[CH:14][CH:15]=[CH:16][C:9]1=[C:8]1[CH:17]=[CH:18][CH:19]=[CH:20][C:7]=21.Cl.N1C=CC=CC=1>O>[CH:5]1[C:6]2[C:11](=[C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]3=[C:8]3[CH:17]=[CH:18][CH:19]=[CH:20][C:7]3=2)[CH:12]=[C:3]([OH:2])[N:4]=1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 59575322HCID 59575322, compound

Product 1

HCID 178515295HCID 178515295, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-methoxydibenzo[f,h]isoquinoline (1.0 g, 3.9 mmol) and pyridine hydrochloride (4.5 g, 39 mmol) were heated at ca. 220° C. for 1.5 h. The reaction was cooled and water was added. The resulting solids were filtered, wash with water and dried in vacuum to give dibenzo[f,h]isoquinolin-3-ol (0.91 g, 95%).

Workup

  1. temperatureThe reaction was cooled
  2. filtrationThe resulting solids were filtered
  3. washwash with water
  4. customdried in vacuum

Sources & evidence

ORD record
ord-368d2997449b4519955eaedd53a7f83c
Source dataset
uspto-grants-2015_04
Patent number
US09005771B2

Reaction notes

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