Pyridine → HCID 59575351, compound

Participants

Reaction Steps

Trifluoromethanesulfonic anhydride (5.2 g, 19 mmol) was added to a mixture of dibenzo[f,h]isoquinolin-3-ol (0.91 g, 3.7 mmol), pyridine (1.2 g, 15 mmol) and dichloromethane 100 mL under nitrogen at 0° C. and stirred overnight at room temperature. The reaction was quenched with saturated NaHCO3. The organic layer was washed with water and dried on Na2SO4. The residue was purified by flash chromatography on silica (hexane:ethyl acetate) to give (1.1 g, 79%).

Provenance & Evidence