Dimethylformamide → HCID 66824465, compound

Participants

Reaction Conditions

Reaction Steps

2-amino-6-hydrazino-9-(2-hydroxyethyl)-7-methyl-purin-8-one (4.5 g, 18.18 mmol) obtained in step 4,2-furoic acid (2.53 g, 22.5 mmol), HOBT (2.53 g, 18.8 mmol) and N-methylmorpholine were taken in dimethylformamide (40 ml). 1-Ethyl-3(3′-dimethylaminopropryl)carbodiimide hydrochloride (EDCI.HCl) (5.4 g, 28.2 mmol) was added to the reaction mixture and stirred at 25-27° C. for 14 hours. The reaction mixture was evaporated and residue was purified by column chromatography to obtain N′-[2-amino-9-(2-hydroxyethyl)-7-methyl-8-oxo-purin-6-yl]furan-2-carbohydrazide (5.3 g, 84%) as an off white solid.

Provenance & Evidence