Water → HCID 66826985, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[5-amino-1-(cyclopropylmethyl)-8-(2-furyl)-2-oxo-[1,2,4]triazolo[5,1-f]purin-3-yl]ethyl 4-methylbenzenesulfonate obtained in step 7 of C1 (0.045 g, 0.088 mmol), 4-fluorophenol (0.018 g, 0.176 mmol) and K2CO3 (0.036 g, 0.22 mmol) were taken in DMF (2 ml) and stirred at 80° C. for 16 hours. To the reaction mixture water (25 ml) was added and extracted with ethyl acetate (3×20 ml). The crude product was purified by column chromatography to 5-amino-1-(cyclopropylmethyl)-3-[2-(4-fluorophenoxy)ethyl]-8-(2-furyl)-[1,2,4]triazolo[5,1-f]purin-2-one (8 mg, 20%) as an off white solid

Provenance & Evidence