Lithium Hydroxide → HCID 66824471, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 1-[2-[5-amino-1-(cyclopropylmethyl)-8-(2-furyl)-2-oxo-[1,2,4]triazolo[5,1-f]purin-3-yl]ethyl]pyrazole-4-carboxylate obtained in step 1 (0.055 g, 0.115 mmol) was dissolved in solution of tetrahydrofuran (6 ml) and methanol (4 ml). To this reaction mixture a solution of lithium hydroxide (0.013 g, 0.576 mmol, in 2 ml water) was added and stirred at 25-27° C. for 16 hours. The reaction mixture was concentrated and acidified with saturated solution of citric acid to get PH˜2-3 and solid obtained was filtered off and washed with water (10 ml) followed by diethyl ether (15 ml). It was dried to obtain 1-[2-[5-amino-1-(cyclopropylmethyl)-8-(2-furyl)-2-oxo-[1,2,4]triazolo[5,1-f]purin-3-yl]ethyl]pyrazole-4-carboxylic acid (0.025 g, 49%) as an off white solid.

Provenance & Evidence