Thionyl Chloride → HCID 66825776, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-[2-[5-amino-1-(cyclopropylmethyl)-8-(2-furyl)-2-oxo-[1,2,4]triazolo[5,1-f]purin-3-yl]ethyl]pyrazole-4-carboxylic acid (0.050 g, 0.111 mmol) was taken in thionyl chloride (0.04 ml, 0.557 mmol) and stirred at 75° C. for 2 hours. The reaction mixture was concentrated and residue was dissolved in DCM (2 ml). To the above solution cyclopropyl amine (0.015 ml, 0.222 mmol) was added at 0° C. and stirred at same temperature for 2 hours and filtered to obtain 1-[2-[5-amino-1-(cyclopropylmethyl)-8-(2-furyl)-2-oxo-[1,2,4]triazolo[5,1-f]purin-3-yl]ethyl]-N-cyclopropyl-pyrazole-4-carboxamide (5.0 mg, 9%) as an off white solid.

Provenance & Evidence