Boron tribromide → HCID 66826071, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound 5-amino-3-[2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl]-8-(2-furyl)-1-(2-methoxyethyl)-[1,2,4]triazolo[5,1-f]purin-2-one (Example I2) (0.050 g, 0.095 mmol), in DCM (3 ml) was added BBr3 (0.1 ml, 0.105 mmol) drop wise at 0° C. and stirred at 25° C. for 20 hours. The reaction mixture was quenched with sat. NaHCO3 (25 ml) and extracted with DCM (3×20 ml). The crude product was purified by LCMS to obtain 5-Amino-3-[2-[4-(4-fluorophenyl)piperazin-1-yl]ethyl]-8-(2-furyl)-1-(2-hydroxyethyl)-[1,2,4]triazolo[5,1-f]purin-2-one (5 mg, 10%) as an off white solid

Provenance & Evidence