Potassium Carbonate → HCID 86696637, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-Chloro-N4-[(2,4-dimethoxyphenyl)methyl]pyrimidine-2,4,5-triamine (8.4 g, 27.11 mmol), acetonitrile (400 ml), potassium carbonate (11.2 g, 81.33 mmol) and p-nitrophenyl chloroformate (11.0 g, 54.22 mmol) were stirred at 25° C. for 48 hours. Reaction mixture was cooled to room temperature and filtered through celite bed, washed with cold acetonitrile and evaporated to dryness to obtain pure 2-Amino-6-chloro-9-[(3,4-dimethoxyphenyl)methyl]-7H-purin-8-one (9.0 g, 98%)

Provenance & Evidence