Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 86696637 | HCID 86696637 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86696639 | HCID 86696639 | 98% |
Reaction Steps
A mixture of 2-amino-6-chloro-9-[(3,4-dimethoxyphenyl)methyl]-7H-purin-8-one (8.8 g, 26.21 mmol), DMF (90 ml), potassium carbonate (5.4 g, 39.31 mmol) and methyl iodide (1.96 ml, 31.45 mmol) stirred at 25° C. for 3 hours. Reaction mixture was cooled to 0° C. Water was added and solid obtained was filtered off to obtain 2-amino-6-chloro-9-[(3,4-dimethoxyphenyl)methyl]-7-methyl-purin-8-one (9.0 g, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09006177B2 |
|---|
| Source dataset | uspto-grants-2015_04 |
|---|
| ORD ID | ord-bba7718b3031419ab955fd80c94ade2e |
|---|
| Source note | uspto-grants-2015_04 |
|---|
