4-Methylmorpholine → HCID 66824539, compound

Participants

Reaction Conditions

Reaction Steps

2-amino-9-[(3,4-dimethoxyphenyl)methyl]-6-hydrazino-7-methyl-purin-8-one (4.6 g, 13.38 mmol) obtained in step 4,2-furoic acid (1.5 g, 13.38 mmol), HOBT (1.8 g, 13.38 mmol) and N-methylmorpholine (2.20 ml, 20.07 mmol) were taken in dimethylformamide (15 ml). EDC.HCl (3.8 g, 20.07 mmol) was added to the reaction mixture and stirred at 25-27° C. for 3 hours. Reaction mixture was cooled to 0° C. Water was added and solid obtained was filtered off, washed with cold water, n-hexane and dried to obtain N′-[2-amino-9-[(3,4-dimethoxyphenyl)methyl]-7-methyl-8-oxo-purin-6-yl]furan-2-carbohydrazide (5.5 g, 95) as an off white solid.

Provenance & Evidence