Dimethylformamide → HCID 66825695, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-amino-8-(2-furyl)-1-methyl-3H-[1,2,4]triazolo[5,1-f]purin-2-one (0.1 g, 0.368 mmol), DMF (3 ml), potassium carbonate (0.76 g, 0.553 mmol) and [1-(4-methoxyphenyl)pyrrolidin-3-yl]methyl methanesulfonate (0.115 g, 0.405 mmol) stirred at 60° C. for 48 hours. Reaction mixture was cooled to 0° C. Water was added and solid obtained was filtered off. The crude product was purified by HPLC/MS to obtain 5-amino-8-(2-furyl)-3-[[1-(4-methoxyphenyl)pyrrolidin-3-yl]methyl]-1-methyl-[1,2,4]triazolo[5,1-f]purin-2-one (0.012 g, 7%).

Provenance & Evidence