Isobutylamine → HCID 70980317, compound

HRID 1468653Notes

Reaction equation

HRID 1468653 reaction equation
BrCCOC1C=C(S(C)(=O)=O)C=C(Cl)C=1.[CH2:16]([NH2:20])[CH:17]([CH3:19])[CH3:18].[F:21][C:22]1[CH:23]=[C:24]([CH:32]=[C:33]([S:35]([CH3:38])(=[O:37])=[O:36])[CH:34]=1)[O:25][CH2:26][CH2:27]NCCC>C(O)C>[F:21][C:22]1[CH:23]=[C:24]([CH:32]=[C:33]([S:35]([CH3:38])(=[O:37])=[O:36])[CH:34]=1)[O:25][CH2:26][CH2:27][NH:20][CH2:16][CH:17]([CH3:19])[CH3:18]

Participants

5

Reactant 3

HCID 6558IsobutylamineHCID 709804851-Propanamine, N-[2-[3-fluoro-5-(methylsulfonyl)phenoxy]ethyl]-HCID 86717741HCID 86717741, compound

Product 1

HCID 70980317HCID 70980317, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Preparation according to Example 1 but performed in one portion: 1-(2-bromoethoxy)-3-chloro-5-methylsulfonyl-benzene (0.05 g, 0.16 mmol) and isobutylamine (0.2 ml, 1.3 mmol) in ethanol (5 ml). MS m/z (relative intensity, 70 eV) 289 (M+, 1), 246 (bp), 138 (2), 86 (70), 56 (17).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-276bb617d7254ecc8ff1b3f7e10d8c23
Source dataset
uspto-grants-2015_04
Patent number
US09006227B2

Reaction notes

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