反应详情

The reaction mixture of (S)-2-(7-bromo-2-chloro-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate (65I) (90 mg, 0.195 mmol), NaOMe in MeOH (25% wt, 66 ul) in MeOH (3 ml) was heated at 50° C. for 20 min in sealed microwave vial. The reaction mixture was washed by sat. NaHCO3, extracted by EtOAc, dried over MgSO4, filtered, concentrated down and purified by silica gel column, eluting by 0-100% EtOAc in Hexanes to give 65J (70 mg, 79%).

1. washThe reaction mixture was washed by sat. NaHCO3
2. extractionextracted by EtOAc
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated down
6. custompurified by silica gel column
7. washeluting by 0-100% EtOAc in Hexanes