HRID1468715

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2724271

2-Chloromethyl 2-(trimethylsilyl)ethyl ether

C6H15ClOSi

反应SMILES：Cc1cc2c(sc(=O)n2C)c(Br)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C

HCID70981530

未命名化合物

反应SMILES：Cc1cc2nc(O)sc2c(Br)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C

HCID178422341

未命名化合物

PRODUCTS

产物

反应SMILES：Cc1cc2c(sc(=O)n2COCC[Si](C)(C)C)c(Br)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C

HCID70981261

未命名化合物

PROCEDURE

实验过程

Prepared by the similar method to make (S)-2-(7-bromo-3,5-dimethyl-2-oxo-2,3-dihydrobenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate (67C) in example 26 from 67B using 2-(trimethylsilyl)ethoxymethyl chloride (SEMCl) instead of methyl iodide.

WORKUP

后处理

customPrepared by the similar method

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-cd70a248388745178d6c5debfa623897
来源数据集: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US09006229B2
来源说明: uspto-grants-2015_04

反应SMILES

[C:1]([O:7][CH2:8][C@H:9]([C:15]1[C:25]([CH3:26])=[CH:24][C:18]2[N:19]([CH3:23])[C:20](=[O:22])[S:21][C:17]=2[C:16]=1[Br:27])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].C(OC[C@H](C1C(C)=CC2N=C(O)SC=2C=1Br)OC(C)(C)C)(=O)C(C)(C)C.[CH3:54][Si:55]([CH3:62])([CH3:61])[CH2:56][CH2:57][O:58]CCl>>[C:1]([O:7][CH2:8][C@H:9]([C:15]1[C:25]([CH3:26])=[CH:24][C:18]2[N:19]([CH2:23][O:58][CH2:57][CH2:56][Si:55]([CH3:62])([CH3:61])[CH3:54])[C:20](=[O:22])[S:21][C:17]=2[C:16]=1[Br:27])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])(=[O:6])[C:2]([CH3:3])([CH3:5])[CH3:4]