Hydrochloric Acid → HCID 178481605, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 2-chloro-1-methyl-1H-[4,4′]bipyrimidinyl-6-one (20 g, 90 mmol) in 1,4-dioxane (200 ml) was added 5N aqueous solution of sodium hydroxide (100 ml) at room temperature. The resulting mixture was heated to 85° C. and stirred for 18 hours. After cooling to room temperature, the reaction mixture was neutralized by the addition of 1N aqueous hydrochloric acid. The resulting solid was collected by filtration and washed by ethyl acetate. 2-Hydroxy-1-methyl-1H-[4,4′]bipyrimidinyl-6-one was then isolated as a white solid (14.5 g, 71 mmol, 79%).

Provenance & Evidence