Water → HCID 68160137, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of lithium aluminum hydride (2.53 g, 66.7 mmol) in tetrahydrofuran (100 ml) was added dropwise methyl (4-piperidin-1-yl-methyl-phenyl)acetate (5.50 g, 22.2 mmol) at 0° C. under nitrogen atmosphere. The mixture was stirred at 0° C. for 2 hours. Water (2.5 ml), 15 wt % aqueous solution of sodium hydroxide (2.5 ml) and water (7.5 ml) was added to the mixture sequentially at 0° C. The mixture was filtrated through a pad of Celite, and concentrated in vacuo. The residue was purified by silica gel column chromatography (eluent; ethyl acetate/methanol=90/10 to 80/20) to afford 2-(4-piperidin-1-yl-methyl-phenyl)ethanol as a colorless oil (4.27 g, 19.5 mmol, 88%).

Provenance & Evidence