Phenyl chloroformate → HCID 136350277, compound

Participants

Reaction Steps

Phenyl (2R)-2-(1-methyl-6-oxo-1,6-dihydro-[4,4]bipyrimidinyl-2-yloxymethyl)pyrrolidine-1-carboxylate was prepared by the same manner as that of methyl 3-(1-methyl-6-oxo-1,6-dihydro-[4,4′]bipyrimidinyl-2-yloxy)piperidine-1-carboxylate except for utilizing (R)-1-methyl-2-(pyrrolidin-2-ylmethoxy)-1H-[4,4′]bipyrimidinyl-6-one (0.20 g, 0.70 mmol) instead of 1-methyl-2-(piperidine-3-yloxy)-1H-[4,4′]bipyrimidinyl-6-one and phenyl chloroformate (125 μl, 1.0 mmol) instead of methyl chloroformate. Phenyl (2R)-2-(1-methyl-6-oxo-1,6-dihydro-[4,4′]bipyrimidinyl-2-yloxymethyl)pyrrolidine-1-carboxylate was isolated as a white solid (29 mg, 0.07 mmol, 10%).

Provenance & Evidence