Benzene → HCID 86717784, compound

Participants

Reaction Conditions

Reaction Steps

The product of step C (310 mg, 0.89 mmol), sodium methanesulfinate (109 mg, 1.06 mmol), Cu(OTf)2.C6H6 (89 mg, 0.178 mmol), and MeNHCH2CH2NHMe (0.038 mL, 0.355 mmol) were combined in dimethyl sulfoxide (5 mL) in a glass pressure tube. The solution was purged with nitrogen, sealed, and heated in a 120° C. oil bath overnight. The crude reaction mixture was directly purified by preparative HPLC (C18 reversed phase, gradient elution 10% to 100% MeCN in water with 0.1% formic acid) to yield the desired product.

Provenance & Evidence