Bromide ion → 1-Bromo-4-(bromomethyl)-2-fluorobenzene

HRID 1468829Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]O)=[CH:4][C:3]=1[F:10].[Br-:11]>>[F:10][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:2]=1[Br:1])[CH2:8][Br:11]

Participants

Reactant 2

HCID 259Bromide ion

HCID 20682297(4-Bromo-3-fluorophenyl)methanol

Product 1

HCID 116661761-Bromo-4-(bromomethyl)-2-fluorobenzene

Procedure

The product from step A was converted to the bromide according to the procedure from example 5 (step A). 1H NMR (500 MHz, CDCl3) δ 7.54 (m, 1H), 7.19 (d, 1H), 7.08 (d, 1H), 4.43 (s, 2H).

Sources & evidence

ORD record: ord-080bc31f24f846b69dfa606decb43230
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09006228B2

Reaction notes

Loading…