2-Chloro-5-ethylpyrimidine → HCID 71136237, compound

HRID 1468833Notes

Reaction equation

HRID 1468833 reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][CH2:8][C@@H:9]2[CH2:11][C@@H:10]2[CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[C:4]([F:20])[CH:3]=1.Cl[C:22]1[N:27]=[CH:26][C:25]([CH2:28][CH3:29])=[CH:24][N:23]=1>>[CH2:28]([C:25]1[CH:24]=[N:23][C:22]([N:15]2[CH2:14][CH2:13][CH:12]([C@H:10]3[CH2:11][C@H:9]3[CH2:8][O:7][CH2:6][C:5]3[CH:18]=[CH:19][C:2]([Br:1])=[CH:3][C:4]=3[F:20])[CH2:17][CH2:16]2)=[N:27][CH:26]=1)[CH3:29]

Participants

3

Reactant 2

HCID 35727632-Chloro-5-ethylpyrimidineHCID 71136793HCID 71136793, compound

Product 1

HCID 71136237HCID 71136237, compound

Procedure

This compound was prepared from the product of step A and 2-chloro-5-ethylpyrimidine according to the conditions outlined in intermediate 7 (step B). 1H NMR (500 MHz, CDCl3) δ 8.19 (s, 2H), 7.33-7.31 (m, 2H), 7.26 (d, J 9.0 Hz, 1H), 4.72-4.65 (m, 2H), 4.60 (d, J 12.4 Hz, 1H), 4.52 (d, J 12.4 Hz, 1H), 3.65 (dd, J 10.1 & 6.4 Hz, 1H), 3.47 (t, J 9.6 Hz, 1H), 2.88-2.76 (m, 2H), 2.47 (q, J 7.5 Hz, 1H), 1.95 (d, J 13.0 Hz, 1H), 1.82 (d, J 13.3 Hz, 1H), 1.45-1.35 (m, 2H), 1.21 (t, J 7.5 Hz, 3H), 1.09-1.00 (m, 1H), 0.79-0.69 (m, 2H), 0.09-0.04 (m, 1H).

Sources & evidence

ORD record
ord-7a44cace599a469fb41d11085dd78ed7
Source dataset
uspto-grants-2015_04
Patent number
US09006228B2

Reaction notes

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