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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1468837Generated: October 25, 2026

(4-Methanesulfonylphenyl)methanol → 5-isopropyl-2-{4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidin-1-yl}pyrimidine

https://huagongshe.com/reaction/1468837

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Methanesulfonylphenyl)methanolHCID 3801026—
Reactant{(1R,2R)-2-[1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}methanolHCID 71128800—
ReactantHCID 86717787HCID 86717787—
Product5-isopropyl-2-{4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidin-1-yl}pyrimidineHCID 71128804—

Reaction Steps

Using the procedure outlined in intermediate 8 (step B) the product from step C was reacted with 4-(methylsulfonyl)benzyl alcohol to yield the title compound. MS (ESI) m/z 444 [M+H]+. GPR119 Human EC50: 0.26 nM

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09006228B2
Source datasetuspto-grants-2015_04
ORD IDord-d0e9665830b04af08dd3e5b763fbca13
Source noteuspto-grants-2015_04