HRID1468840
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 90 °C
PROCEDURE
实验过程
The product of step A (100 mg, 0.2 mmol), Pd(PPh3)2Cl2 (16 mg, 0.02 mmol), and 2-(tributylstannyl)oxazole (125 mg, 0.35 mmol) were dissolved in toluene (2.5 mL), and the solution was heated at 90° C. for 18 h. Silica gel was added, and the slurry was subjected to silica gel column chromatography (2/1 EtOAc/hexanes) to provide the title compound. MS (ESI) m/z 419 [M+H]+. GPR119 Human EC50: 12 nM
WORKUP
后处理
- additionSilica gel was added