HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-Methyloxirane → (2S)-1-{4-[({(1R,2R)-2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}methoxy)methyl]phenyl}propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-Methyloxirane | HCID 146262 | — |
| Reactant | 2-[4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidin-1-yl]-5-ethyl pyrimidine | HCID 71135272 | — |
| Product | (2S)-1-{4-[({(1R,2R)-2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}methoxy)methyl]phenyl}propan-2-ol | HCID 71136245 | — |
Reaction Steps
This compound was prepared from the product of example 54 (step A), and (S)-propylene oxide according to the procedure from example 58. MS (ESI) m/z 410 [M+H]+. GPR119 Human EC50: 1.6 nM
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006228B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-761ba5c492a141b6956b9c1e524802bb |
| Source note | uspto-grants-2015_04 |