Hydrochloric Acid → HCID 86717804, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4 M HCl in dioxane (3.85 mL, 15.4 mmol) was added to a solution of tert-butyl 2-(3-fluoro-4-((((1R,2R)-2-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)cyclopropyl)methoxy)methyl)phenyl)acetate (Step C product, 750 mg, 1.54 mmol) in DCM (4 mL). This mixture was stirred at 35° C. for 4 hrs. The reaction mixture was subsequently concentrated under reduced pressure to afford the title compound (1.05 g, 97%) as a crude product to be used for the next step. LC/MS (m/z): 432 (M+H)+.

Provenance & Evidence