HRID14689

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31738

4-Benzylpiperidine

C12H17N

结构：COc1cc2c(CC(=O)O)cnc(CNC(=O)OC(C)(C)C)c2cc1OC

HCID68613423

未命名化合物

PRODUCTS

生成物

结构：COc1cc2c(CC(=O)N3CCC(Cc4ccccc4)CC3)cnc(CNC(=O)OC(C)(C)C)c2cc1OC

HCID68612809

未命名化合物

PROCEDURE

实验过程

As described in Example 1, 94 mg of [1-(tert-butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetic acid was coupled with 4-benzyl-piperidine to give 132 mg of {-4-[2-(4-benzyl-piperidin-1-yl)-2-oxo-ethyl]-6,7-dimethoxy-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester. MS: APCI (M+H) calc'd for C31H39N3O5+H 534.7; found 534.1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-54a4ba20247247e9b40c80e9c9f78ecd
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07732446B1
来源说明: uspto-grants-2010_06

反应 SMILES

[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[C:13]([CH2:24][C:25](O)=[O:26])=[CH:12][N:11]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:28]([CH:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[C:1]([O:5][C:6](=[O:7])[NH:8][CH2:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=2)[C:13]([CH2:24][C:25]([N:38]2[CH2:39][CH2:40][CH:35]([CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:36][CH2:37]2)=[O:26])=[CH:12][N:11]=1)([CH3:3])([CH3:2])[CH3:4]