反应详情

温度

-2.5 °C

4-Bromo-3-chloro-2-nitroaniline (4.1 g, 16 mmol) was dissolved in 60 mL ethanol, treated with 45% potassium hydroxide solution (2.0 g, 16 mmol), cooled to −5 to 0° C. and treated drop wise with commercial bleach solution (32 mL, 6 wt. %, 31 mmol) over 20 min. The mixture was stirred for 90 min at 0-15° C. and poured into 700 mL water. The precipitated product was collected by filtration, washed well with water and then dried under vacuum at 80° C. to give the title compound (3.2 g, 81%): EIMS m/z 248.

1. additiontreated drop wise with commercial bleach solution (32 mL, 6 wt. %, 31 mmol) over 20 min
2. filtrationThe precipitated product was collected by filtration
3. washwashed well with water
4. customdried under vacuum at 80° C.