Hydrochloric Acid → HCID 90403914, compound

Participants

Reaction Conditions

Reaction Steps

A 2M solution of aqueous sodium hydroxide (620 microliters (μL), 1.2 mmol) was added to a stirred suspension of methyl 4-amino-6-(benzo[c][1,2,5]oxadiazol-5-yl)-3-chloro-5-fluoropicolinate (200 mg, 0.62 mmol) in methanol (1.3 mL) at 23° C. The heterogeneous light brown mixture was stirred at 23° C. for 72 h. The reaction mixture was adjusted to approximately pH=4 via dropwise addition of concentrated hydrochloric acid and concentrated via rotary evaporation. The residue was slurried in water and vacuum filtered to afford the title compound (120 mg, 63% yield).

Provenance & Evidence