HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(1-Aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-1-(4-benzyl-piperidin-1-yl)-ethanone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | {4-[2-(4-Benzyl-piperidin-1-yl)-2-oxo-ethyl]-6,7-dimethoxy-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester | HCID 68612809 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(1-Aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-1-(4-benzyl-piperidin-1-yl)-ethanone hydrochloride | HCID 68614430 | 100% |
Reaction Steps
As described in Example 1, 94 mg of {4-[2-(4-benzyl-piperidin-1-yl)-2-oxo-ethyl]-6,7-dimethoxy-isoquinolin-1-ylmethyl}-carbamic acid tert-butyl ester was treated with HCl in EtOAc to give 114 mg (>100%) of 2-(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-yl)-1-(4-benzyl-piperidin-1-yl)-ethanone hydrochloride. MS: APCI (M+H) calc'd for C26H31N3O3+H 434.5; found 434.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732446B1 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-7db0b5e82ddb4f8f9821ef7ecfe6591d |
| Source note | uspto-grants-2010_06 |