Morpholine → HCID 66747652, compound

HRID 1469015Notes

Reaction equation

HRID 1469015 reaction equation
[CH3:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[C:3]=1[CH2:4][NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[F:16])[N:12]=[C:11]([N:17]1[CH:21]=[C:20]([C:22]([O:24]CC)=[O:23])[CH:19]=[N:18]1)[NH:10][C:9]2=O.[NH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[CH3:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([CH3:32])[C:3]=1[CH2:4][NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][C:15]=1[F:16])[N:12]=[C:11]([N:17]1[CH:21]=[C:20]([C:22]([OH:24])=[O:23])[CH:19]=[N:18]1)[N:10]=[C:9]2[N:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 136387802HCID 136387802, compound

Product 1

HCID 66747652HCID 66747652, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(6-((2,6-dimethylbenzyl)amino)-7-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and morpholine in step E. MS (ESI): predicted mass calcd. for C25H25FN6O3, 476.2

Sources & evidence

ORD record
ord-e77b39f18b674c9e9f05399a2aac58a5
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

Loading…