Morpholine → HCID 56655774, compound

HRID 1469018Notes

Reaction equation

HRID 1469018 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[NH:7][C:8]([N:12]3[CH:16]=[C:15]([C:17]([O:19]CC)=[O:18])[CH:14]=[N:13]3)=[N:9]2)=[CH:4][C:3]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH3:29].[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)=[N:7][C:8]([N:12]3[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[CH:14]=[N:13]3)=[N:9]2)=[CH:4][C:3]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[CH3:29]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 136379422HCID 136379422, compound

Product 1

HCID 56655774HCID 56655774, compound

Procedure

The above compound may be made analogous to Example 1 using ethyl 1-(7-fluoro-4-oxo-6-(o-tolyl)-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylate in step D and morpholine in step E. MS (ESI): predicted mass calcd. for C23H20FN5O3, 433.2

Sources & evidence

ORD record
ord-7f0cb65c07ec4032ab144a71d67d7fda
Source dataset
uspto-grants-2015_04
Patent number
US09006251B2

Reaction notes

Loading…